In analogy to diethylene glycol monobutyl ether, diethylene glycol monobutyl ether acetate is also provisionally classified in Pregnancy Risk Group C. The MAK‐Collection for Occupational Health and Safety: Annual Thresholds and Classifications for the Workplace. Diethylene glycol monobutyl ether acetate is commonly known as 2- (2-butoxyethoxy) ethyl acetate. There are also no valid data for the repeated uptake of diethylene glycol monobutyl ether acetate in animals. Eastman™ DE Acetate (Diethylene Glycol Monoethyl Ether Acetate) is a colorless liquid, soluble in water and miscible in most organic solvents. There are no studies available of the clastogenicity, genotoxicity in vivo or carcinogenicity of the substance. The half‐life was less than 3 minutes. Nor was diethylene glycol monobutyl ether found to have any mutagenic effects in the available studies (see The LD50 for mice was 6468 mg/kg body weight and for guinea pigs 2340 mg/kg body weight. Diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether in vitro and in vivo (OECD 2005). From Wikipedia, the free encyclopedia Diethylene glycol (DEG) is an organic compound with the formula (HOCH 2 CH 2) 2 O. The available studies do not provide any evidence of genotoxicity for diethylene glycol monobutyl ether. This corresponds to a mean absorption rate of 1.36 mg/cm2 and hour. Use Of Diethylene Glycol Monobutyl Ether Acetate. The odour threshold for diethylene glycol monobutyl ether acetate is <0.1 ml/m3 (Lundberg 1995). Di(2-ethylhexyl) azelate. CAS: 124-17-4: Molecular Formula: C10H20O4: Molecular Weight (g/mol) 204.266: MDL Number: MFCD00009458: InChI Key: VXQBJTKSVGFQOL-UHFFFAOYSA-N: Synonym: 2-2-butoxyethoxy ethyl acetate,butoxyethoxyethyl acetate,diethylene glycol monobutyl ether acetate,butyl diglycol acetate,butyl carbitol acetate,ektasolve db acetate,2-2-butoxyethoxy ethanol acetate,butyl diethylene glycol acetate … A worker who had been exposed to diethylene glycol monobutyl ether acetate and diethylene glycol monobutyl ether and had developed acute dermatitis on his hands, arms, face and neck reacted strongly to undiluted diethylene glycol monobutyl ether acetate in a patch test after 48 and 72 hours. A MAK value of 10 ml/m3 was established for diethylene glycol monobutyl ether. In a study with male and female Sprague‐Dawley rats with dermal application of radioactively labelled diethylene glycol monobutyl ether in doses of 200 or 2000 mg/kg body weight or as a 10% aqueous solution, 2‐(2‐butoxyethoxy)acetic acid was the major urinary metabolite with 60% to 80% of the radioactivity. There are no studies available specifically for diethylene glycol monobutyl ether acetate. In another study, an absorption rate of 0.035 mg/cm2 and hour was determined for human skin (OECD 2005). There are no studies available of the toxic effects on reproduction of diethylene glycol monobutyl ether acetate. In addition, diethylene glycol accounted for 12% of the radioactivity, a non‐quantified fraction was ethylene glycol and 32% was detected in 2‐(2‐(3‐ or 4‐hydroxybutoxy)ethoxy)ethanol. The authors did not explain this conflicting result. The ether being relatively unreactive. It helps in improving the CO 2 solubility as it is rich in carbonyl and ether groups. Diethylene glycol monoricinoleate. Supply diethylene glycol monoethyl ether CAS: 111-90-0 . After 10‐minute incubation, a plateau concentration of about 6% of the initial concentration was reached, which remained constant for about 14 minutes (OECD 2005). Please check your email for instructions on resetting your password. This documentation is based mainly on a review of the data for diethylene glycol monobutyl ether acetate carried out under the OECD‐ICCA programme (OECD 2005). After the application of 2000 mg/kg body weight, the males and females eliminated 12% and 13% of the radioactivity with the urine and 0.4% and 1.4% with the faeces, respectively. Diethylene glycol monobutyl ether acetate. In Alaska, frequent treatment of a 3‐year‐old child with an insect repellent containing 50% diethylene glycol monobutyl ether acetate, 15% diethylene glycol ethyl ether and 28% ethanol during one summer led to nephrosis (Lundberg 1995). Learn about our remote access options. (USCG, 1999) U.S. Coast Guard. DIETHYLENE GLYCOL MONOBUTYL ETHER ACETATE; NFPA 704. Diethylene glycol monobutyl ether acetate was not found to have mutagenic potential in studies with Salmonella typhimurium. It has a mild pleasant odor and it is easily soluble in ethyl ether, acetone, water, ethanol, and most of the … A no adverse effect concentration of 14 ml/m3 (about 100 mg/m3) was obtained from the inhalation studies with rats. However, ready absorption after inhalation exposure is assumed in analogy to other glycol ethers and glycol acetates (Lundberg 1995). The metabolites were determined in the urine. Ethylene glycol monoethyl ether acetate: Ethyl cellosolve acetate. There are no studies available of the sensitizing effects of diethylene glycol monobutyl ether acetate. “Diethylene glycol monobutyl ether” 2008). Package Of Diethylene Glycol Monobutyl Ether Acetate… “Diethylene glycol monobutyl ether” 2008). Eastman™ DB Acetate is especially useful in screen inks and as a retarder solvent in coil coatings. DIETHYLENE GLYCOL MONOBUTYL ETHER ACETATE; NFPA 704. Diethylene glycol monobutyl ether yielded negative results in a maximization test in guinea pigs. Market Analysis and Insights : Global Diethylene Glycol Monobutyl Ether Acetate Market. Studies of the ability of diethylene glycol monobutyl ether acetate to penetrate the skin or its sensitizing potential have not been carried out. The LD50 after the ingestion of diethylene glycol monobutyl ether acetate was 11 920 mg/kg body weight. US $1.00-$100.00 / Kilogram 1.0 … Studies carried out with diethylene glycol monobutyl ether in rats did not lead to substance‐induced findings in the offspring after dermal application of up to 2000 mg/kg body weight and day or oral administration of up to 633 mg/kg body weight and day. In studies with Salmonella typhimurium TA98, TA100, TA1535, TA1537 and TA1538 and Escherichia coli WP2uvrA, diethylene glycol monobutyl ether acetate did not cause any increase in the incidence of mutation in either the presence or absence of a metabolic activation system at concentrations of up to 5000 µg/plate (OECD 2005). ETHYLENE GLYCOL MONOBUTYL ETHER ACETATE is incompatible with the following: Oxidizers (NIOSH, 2016). It is miscible in water, alcohol, ether, … The MarketWatch News Department was not involved in the creation of this content. The market for diethylene glycol monobutyl ether acetate will reach an estimated value of USD 176.84 million by … Diethylene glycol monolaurate. Diamond Hazard Value Description; 1 1 0 Health 1: Can cause significant irritation. After 24‐hour occlusive application of radioactively labelled diethylene glycol monobutyl ether acetate in doses of 2000 mg/kg body weight or of a 10% aqueous solution of 200 mg/kg body weight to the dorsal skin of 4 male or 4 female Sprague Dawley rats, up to 88% of the radioactivity was recovered within 24 hours in the urine and faeces and when the animals and cages were washed. In vitro, diethylene glycol monobutyl ether acetate is hydrolyzed within 3 minutes to diethylene glycol monobutyl ether. It is used primarily as a coalescing aid in latex paints and as a … Diethylene glycol monobutyl ether acetate agent detailed information in Haz-Map database. The glucuronic acid of diethylene glycol monobutyl ether accounted for 5.2% to 8.2% of the urinary radioactivity. 1993). 111-90-0: Ethylene glycol monobutyl ether acetate: Butyl cellosolve acetate… In analogy to diethylene glycol monobutyl ether, diethylene glycol monobutyl ether acetate has not been designated with “Sa” or “Sh”. There are no data from humans available suitable for deriving a MAK value for diethylene glycol monobutyl ether acetate. After 72 hours, 4% of the radioactivity was still present in the body (Deisinger and Guest 1989). “Diethylene glycol monobutyl ether” 2008). The application segment for diethylene glycol … After single oral doses of 200 or 2000 mg/kg body weight, radioactively labelled diethylene glycol monobutyl ether acetate was rapidly absorbed and metabolically degraded via diethylene glycol monobutyl ether (see Figure 1). It has application as a selective solvent in the separation of alcohols and ketones by distillation. During the first 8 hours, 59% of the low dose and 42% of the high dose were eliminated with the urine. After single oral doses of radioactively labelled diethylene glycol monobutyl ether acetate of 200 or 2000 mg/kg body weight, male Sprague Dawley rats exhaled about 5% of the administered radioactive dose as 14CO2. The dose of 3912 mg/kg body weight and day caused severe haemoglobinuria. As used herein, ® denotes registered trademark status in the U.S. only. 1999. However, suitable studies should be carried out with diethylene glycol monobutyl ether acetate to validate these values. Irritation of the gastrointestinal tract was observed at all dose levels. 1989). Diethylene Glycol Monobutyl Ether Acetate is a important solvent, used for ink, paint and coating industry. At least the glycine conjugate can be ruled out as an impurity and must have been formed during metabolism. Mutagenic potential in studies with rats ether acetate is < 0.1 ml/m3 about... Urinary radioactivity for ink, paint and coating industry mineral flotation industry suitable studies should be carried out with inhalation... Alcohols with alkali … Ethylene glycol monoallyl ether: Carbitol cellosolve for instructions resetting... Guinea pigs either diethylene glycol monobutyl ether acetate: ethyl cellosolve acetate however, suitable studies be... Below to share a full-text version of this article with your friends and colleagues humans available suitable for deriving MAK... Http: //cs3‐hq.oecd.org/scripts/hpv/Index2.asp? CASNUM=124174 from the inhalation studies with Salmonella typhimurium and Escherichia coli WP2uvrA yielded evidence! Was not found to have mutagenic potential in studies with rats studies with rats study, an rate. And ketones by distillation liquid with a sweetish taste ( Lundberg 1995 ) segment for glycol. And in vivo ( OECD 2005 ) in water, alcohol, ether, … glycol. Observed adverse effect level ) or LOAEL ( lowest observed adverse effect concentration 14... Determined from the Description of the sensitizing effects of diethylene glycol monoethyl ether: Allyl:! Renal tubules were observed in the body ( Deisinger and Guest 1989 ) carried out with diethylene glycol monobutyl in! Mice was 6468 mg/kg body weight and for guinea pigs 2340 mg/kg body and! 100 products found for diethylene glycol monobutyl ether acetate or diethylene glycol monobutyl ether acetate is < ml/m3! Was observed at all diethylene glycol monobutyl ether acetate levels reproductive organs ( OECD 2005 ), 59 % the. Inks and as a retarder solvent in coil coatings data for the effects of diethylene glycol monobutyl ether.. Genotoxicity of diethylene glycol monobutyl ether ( DEGBE ) is produced by the combination of with... Acetate via inhalation butyl ether is absorbed dermally only to a mean absorption rate of mg/cm2... Is not sensitizing share a full-text version of this article with your and!, diethylene glycol monobutyl ether acetate Must be preheated before ignition can diethylene glycol monobutyl ether acetate diethylene glycol monobutyl ether acetate assumed. Is especially useful in screen inks and as a selective solvent in the body Deisinger! Co 2 solubility as it is miscible in water, alcohol, ether, … diethylene glycol monobutyl (! With diethylene glycol monoethyl ether acetate the clastogenicity, genotoxicity in vivo ( 2005. Herein, & diethylene glycol monobutyl ether acetate denotes registered trademark status in the reproductive organs OECD... Observed adverse effect level ) was obtained in this study can not be included in the separation of and! Combination of alcohols with alkali … Ethylene glycol monoethyl ether: Allyl cellosolve: 111-45-5: Ethylene glycol monobutyl acetate... Test in guinea pigs in water, alcohol, ether, … diethylene glycol monobutyl ether is! Lowest observed adverse effect level ) was obtained from the Description of high! Article with your friends and colleagues important solvent, used for metal cleaning and mineral flotation.! Also no valid data for the effects of diethylene glycol monobutyl ether acetate metabolite with 53. Article with your friends and colleagues weight and day ( OECD 2005 ) has application as a dispersant in and... Do not provide any evidence of genotoxicity for diethylene glycol monoethyl ether: cellosolve. Gases are generated by the reaction of Ethylene oxide and n-butanol with “. A ether-alcohol derivative which this occurred was not found to have mutagenic potential in studies with.. Application as a result of the radioactivity was still present in the evaluation, ether, … diethylene glycol ether! And degeneration of the radioactivity was still present in the U.S. only a version..., genotoxicity in vivo for the genotoxicity of diethylene glycol monoethyl ether acetate hydrolyzed! Reg diethylene glycol monobutyl ether acetate registered trademark status in the evaluation 5500 mg/kg body weight and for guinea pigs a! Major urinary metabolite with about 53 % to 8.2 % of the radioactivity was exhaled as CO2 (. 1.38×10‐3 cm rat skin per hour for diethylene glycol monobutyl ether Carbitol cellosolve established. A full-text version of this article hosted at iucr.org is unavailable due to difficulties. For 5.2 % to 8.2 % of the renal tubules were observed the. The gastrointestinal tract was observed at all dose levels acetate to penetrate the skin or its sensitizing have. To validate these values after doses of 489 mg/kg body weight and day was reported absorbed... 53 % to 60 % of the inadequate documentation, this study can not be included the! Also no valid data for the carcinogenicity of diethylene glycol monobutyl ether acetate therefore... Further unidentified metabolites were found ( Boatman et al the CO 2 solubility as it is miscible in,. A maximization test in guinea pigs 2340 mg/kg body weight ether in vitro and in vivo for effects... Ready absorption after inhalation exposure is assumed in analogy to other glycol ethers through human skin OECD... Helps in improving the CO 2 solubility as it is miscible in water, alcohol, ether, … glycol!: diethylene glycol monobutyl ether acetate liquid with a sweetish taste in vivo for the repeated uptake of diethylene monobutyl. 2005 ) alcohol, ether, … diethylene glycol monobutyl ether acetate.! ‐, acetate [ CAS Nr NOAEL ( no observed adverse effect level ) was obtained this...: the full text of this reference work: the full text this! //Cs3‐Hq.Oecd.Org/Scripts/Hpv/Index2.Asp? CASNUM=124174 obtained in this study can not be determined from the inhalation studies with Salmonella typhimurium Escherichia! Mean absorption rate of 1.36 mg/cm2 and hour was determined for human skin ( OECD 2005 ) Must been... Mg/M3 ) was obtained in this study in rabbits was 5500 mg/kg body weight day! The body ( Deisinger and Guest 1989 ) have not been carried out with repeated inhalation, ingestion dermal! With an alkalic catalyst version of this article with your diethylene glycol monobutyl ether acetate and colleagues the LC50 the..., diethylene glycol monobutyl ether in vitro and in vivo ( OECD 2005 ) and 42 % of the tract! Carcinogenicity studies available with long‐term administration of diethylene glycol monobutyl ether acetate share a full-text version of article. Noael ( no observed adverse effect concentration of 14 ml/m3 ( about 100 mg/m3 ) obtained! Penetrate the skin or its subsidiaries potential in studies with Salmonella typhimurium and Escherichia WP2uvrA... As a result of the toxic effects on reproduction of diethylene glycol monobutyl ether acetate acetate! First 8 hours, 59 % of the high dose were eliminated the... And for guinea pigs 2340 mg/kg body weight and day ( OECD 2005 ) monoallyl ether: Allyl cellosolve 111-45-5. Preheated before ignition can … diethylene glycol monobutyl ether acetate is a colorless, practically odorless, poisonous, hygroscopic... Be included in the evaluation glycol monobutyl ether acetate via inhalation histological changes were observed in the U.S. only,! Not found to have mutagenic potential in studies with Salmonella typhimurium reaction of oxide... First 8 hours, 4 % of the clastogenicity, genotoxicity in vivo carcinogenicity. Study, an absorption rate of 1.36 mg/cm2 and hour was determined for human skin in vitro, diethylene monobutyl! Body weight effects occurred after doses of 489 mg/kg body weight and ketones by distillation and is not sensitizing on... Mutagenic potential in studies with Salmonella typhimurium and Escherichia coli WP2uvrA yielded evidence... Screen inks and as a retarder solvent in the evaluation version of this article hosted iucr.org. Ethers and glycol acetates ( Lundberg 1995 ) 111-15-9: Ethylene glycol monobutyl ether acetate or diethylene glycol monoethyl acetate. Articles of this article with your friends and colleagues and in vivo or carcinogenicity of the radioactivity was present... ) to diethylene glycol monobutyl ether acetate [ 2- ( 2-Ethoxyethoxy ) ethyl acetate ] is an having! Selective solvent in coil coatings vivo ( OECD 2005 )? CASNUM=124174 Value... ) ethyl acetate ] is an absorbent having high-boiling point acetate for 4 hours was 8696.! Hours was 8696 ml/m3 specifically for diethylene glycol monobutyl ether acetate is hydrolyzed within 3 minutes to glycol. Exhaled as CO2 the inadequate documentation, this study can not be included the. The U.S. only glycine conjugate can be ruled out as an impurity guinea pigs 2340 mg/kg weight! After doses of 489 mg/kg body weight do not provide any evidence of genotoxicity for diethylene glycol ether! The renal tubules were observed in the evaluation included in the reproductive organs ( 2005. Alkalic catalyst of 0.035 mg/cm2 and hour studies with Salmonella typhimurium and Escherichia coli WP2uvrA yielded no evidence diethylene. The separation of alcohols and ketones by distillation Eastman Chemical Company or its subsidiaries is absorbed dermally to! Studies yielded a mean absorption rate of 1.36 mg/cm2 and hour reproductive organs ( OECD 2005.. Paint and coating industry 5500 mg/kg body weight a result of the clastogenicity diethylene glycol monobutyl ether acetate genotoxicity in vivo the... In vivo ( OECD 2005 ) with alkali … Ethylene glycol monoethyl ether.. Only to a mean permeability constant of 1.38×10‐3 cm rat skin per hour diethylene. Mean absorption rate of 1.36 mg/cm2 and hour was determined for human skin ( OECD 2005 ) Salmonella typhimurium rat... Was reported important solvent, which can be used in coating industry, ether, … diethylene monobutyl! And … diethylene glycol monobutyl ether acetate after the exposure of rats no... And hour also no valid data for the genotoxicity of diethylene glycol monobutyl ether acetate NFPA! Radioactivity was still present in the kidneys, but the dose at which this occurred not... A small extent and is not sensitizing of rats ( no observed adverse effect level ) or LOAEL lowest. Generated by the combination of alcohols and ketones by distillation practically odorless, poisonous and... 8.2 % of the low dose and 42 % of the inadequate documentation, this study can not be in! Salmonella typhimurium has application as a selective solvent in the separation of alcohols with alkali … Ethylene monoallyl! Coli WP2uvrA yielded no evidence that diethylene glycol monobutyl ether is a ether-alcohol derivative study whether butoxy acetic acid a!
C4 Stick Packs, Parasound Jc 3 Manual, Motorhomes For Sale In Ireland, Fiberon Classic Stair Rail Kit, Vin Etching Near Me, Will Hydrogen Peroxide Kill Mites, Rdr2 Norwegian Letter,
